Kegg Pathways

These table show the average effect on the genes associated to the pathway. Click for details.

1. Metabolism

0.1 Global and overview maps

pathwaygenes glucosesuccinatecitrate
ΔTn6212Δ3ΔLysRΔdctTΔTn6212Δ3ΔLysRΔdctTΔTn6212Δ3ΔLysRΔdctT
Metabolic pathways 714
-0.0633
-0.036
-0.0116
-0.149
0.023
0.0642
0.0485
-0.0222
0.055
0.0254
0.002
0.0665
Biosynthesis of secondary metabolites 289
-0.0541
-0.0447
-0.00564
-0.164
0.0826
0.108
0.0962
0.0208
0.0618
0.00527
-0.014
0.0592
Microbial metabolism in diverse environments 216
-0.0717
-0.0526
-0.0174
-0.216
-0.00525
0.0356
0.0225
-0.0708
0.105
0.0637
0.0212
0.1
Biosynthesis of antibiotics 202
-0.0702
-0.0597
-0.013
-0.202
0.104
0.117
0.109
0.0272
0.0766
0.00583
-0.0174
0.0494
Carbon metabolism 97
-0.0309
-0.046
0.00845
-0.225
0.0668
0.0779
0.0816
-0.00282
0.143
0.0474
0.00766
0.11
2-Oxocarboxylic acid metabolism 26
-0.128
-0.102
-0.0215
-0.267
0.108
0.218
0.146
0.0892
0.0236
-0.0202
-0.0547
-0.0707
Fatty acid metabolism 34
-0.0488
-0.0122
0.0249
-0.139
0.085
0.0673
0.0916
0.0755
0.0952
0.0746
0.04
0.123
Biosynthesis of amino acids 115
-0.0546
-0.0901
-0.011
-0.211
0.183
0.174
0.17
0.0965
0.0604
-0.0508
-0.0647
-0.0211
Degradation of aromatic compounds 14
-0.168
-0.0154
-0.117
-0.223
-0.185
-0.12
-0.201
-0.258
-0.0588
-0.0626
-0.0719
0.00469

1.1 Carbohydrate metabolism

pathwaygenes glucosesuccinatecitrate
ΔTn6212Δ3ΔLysRΔdctTΔTn6212Δ3ΔLysRΔdctTΔTn6212Δ3ΔLysRΔdctT
Glycolysis / Gluconeogenesis 24
0.105
-0.0892
0.0183
-0.304
0.29
0.165
0.139
-0.00409
0.337
0.0492
0.0393
0.13
Citrate cycle (TCA cycle) 22
-0.142
-0.0799
-0.0402
-0.333
0.177
0.261
0.217
0.138
0.0962
0.0413
0.00554
0.129
Pentose phosphate pathway 27
-0.0596
-0.0213
0.0434
-0.18
-0.0324
0.0568
0.0615
-0.0903
0.145
0.114
0.0679
0.185
Pentose and glucuronate interconversions 7
-0.061
-0.0327
0.0638
-0.215
0.0648
0.0908
0.152
0.12
0.0616
-0.0367
-0.0405
0.0449
Fructose and mannose metabolism 18
-0.0919
-0.0583
-0.0124
-0.18
0.0366
0.116
0.126
0.0679
0.0713
0.0395
-0.0112
0.0682
Galactose metabolism 7
-0.0478
-0.0589
0.0756
-0.189
0.098
0.187
0.137
0.014
0.113
0.0505
0.0387
0.109
Ascorbate and aldarate metabolism 9
-0.0865
-0.0107
0.0247
-0.262
0.0993
0.0379
0.133
0.101
-0.0704
-0.076
-0.151
-0.112
Starch and sucrose metabolism 22
0.0713
-0.00849
0.12
-0.0538
-0.0549
0.0744
0.0268
-0.01
0.151
0.159
0.123
0.239
Amino sugar and nucleotide sugar metabolism 28
-0.0559
-0.0463
0.0312
-0.167
0.122
0.17
0.168
0.153
0.115
0.0507
0.0289
0.114
Pyruvate metabolism 38
-0.105
-0.0709
-0.00675
-0.29
0.0728
0.149
0.142
0.0544
0.119
0.0602
0.0282
0.128
Glyoxylate and dicarboxylate metabolism 36
-0.0769
-0.0581
0.00417
-0.207
-0.154
-0.0707
-0.0576
-0.17
0.1
0.0816
0.031
0.15
Propanoate metabolism 30
-0.106
-0.0261
-0.016
-0.255
-0.131
0.017
-0.0216
-0.16
0.102
0.0733
0.0268
0.125
Butanoate metabolism 28
-0.0911
-0.0173
-0.0365
-0.204
-0.0997
0.00742
-0.0693
-0.112
0.0574
0.0703
0.0325
0.106
C5-Branched dibasic acid metabolism 6
-0.169
-0.107
-0.0572
-0.286
0.322
0.401
0.322
0.397
-0.129
-0.193
-0.182
-0.182
Inositol phosphate metabolism 15
-0.0812
0.0089
-0.0344
-0.225
-0.031
0.011
0.0173
-0.208
0.0743
0.045
-0.0144
0.0832

2.1 Energy metabolism

pathwaygenes glucosesuccinatecitrate
ΔTn6212Δ3ΔLysRΔdctTΔTn6212Δ3ΔLysRΔdctTΔTn6212Δ3ΔLysRΔdctT
Oxidative phosphorylation 33
0.139
0.027
0.0199
-0.0089
0.369
0.178
0.155
0.0874
0.216
0.0896
0.064
0.113
Photosynthesis 7
-0.0855
0.0233
-0.0296
-0.147
0.472
0.352
0.36
0.26
0.0675
0.0362
0.0273
0.111
Carbon fixation in photosynthetic organisms 14
-0.0753
-0.0905
0.0182
-0.203
0.221
0.236
0.268
0.19
0.00881
-0.106
-0.0772
-0.00407
Carbon fixation pathways in prokaryotes 28
-0.0619
-0.02
0.029
-0.194
0.0968
0.12
0.148
0.142
0.11
0.074
0.0194
0.12
Methane metabolism 17
0.213
-0.0884
0.0215
-0.265
0.35
0.0966
0.117
0.0372
0.374
0.0134
-0.0273
0.0471
Nitrogen metabolism 13
-0.142
-0.0956
-0.043
-0.229
-0.00984
-0.0241
0.0489
-0.119
0.0772
0.0878
0.0585
0.108
Sulfur metabolism 35
-0.178
-0.0571
-0.0634
-0.378
-0.558
-0.426
-0.304
-0.182
-0.174
-0.0688
-0.173
-0.396

3.1 Lipid metabolism

pathwaygenes glucosesuccinatecitrate
ΔTn6212Δ3ΔLysRΔdctTΔTn6212Δ3ΔLysRΔdctTΔTn6212Δ3ΔLysRΔdctT
Fatty acid biosynthesis 23
-0.0443
-0.0109
0.0143
-0.105
0.177
0.119
0.152
0.174
0.0792
0.0272
0.019
0.0826
Fatty acid degradation 17
-0.0948
-0.0468
-0.0095
-0.243
-0.0678
0.00202
-0.00531
-0.127
0.0856
0.109
0.0398
0.142
Synthesis and degradation of ketone bodies 7
-0.0688
-0.0274
0.0321
-0.252
-0.0372
-0.0441
0.00206
-0.0695
0.0479
0.0598
0.000582
0.0637
Glycerolipid metabolism 6
0.073
0.0571
0.0109
0.0238
0.198
0.227
0.212
0.17
0.0691
0.0157
0.051
0.137
Glycerophospholipid metabolism 20
0.0259
0.0191
0.0406
-0.0167
-0.036
0.0591
0.0146
-0.0688
0.149
0.14
0.11
0.218
Ether lipid metabolism 2
0.105
0.02
0.0658
-0.0185
-0.0729
-0.0652
-0.0123
0.0667
0.126
0.116
0.124
0.206
Arachidonic acid metabolism 3
-0.0792
0.00946
-0.0477
-0.129
-0.256
-0.121
-0.199
-0.36
0.023
-0.0417
0.0193
0.0175
alpha-Linolenic acid metabolism 2
-0.146
-0.0832
0.0412
-0.367
-0.0327
-0.0197
0.00865
-0.223
0.195
0.282
0.197
0.325
Biosynthesis of unsaturated fatty acids 3
-0.0514
-0.0256
-0.0787
0.0449
-0.233
-0.104
-0.224
-0.45
0.13
0.111
0.0607
0.19

4.1 Nucleotide metabolism

pathwaygenes glucosesuccinatecitrate
ΔTn6212Δ3ΔLysRΔdctTΔTn6212Δ3ΔLysRΔdctTΔTn6212Δ3ΔLysRΔdctT
Purine metabolism 61
-0.0669
-0.0335
-0.00261
-0.129
-0.0138
0.0552
0.0331
-0.0616
0.0397
0.0368
0.0135
0.0762
Pyrimidine metabolism 26
-0.117
-0.0332
-0.0523
-0.158
0.0705
0.0763
0.0825
-0.034
-0.0166
-0.0539
-0.0268
-0.00409

5.1 Amino acid metabolism

pathwaygenes glucosesuccinatecitrate
ΔTn6212Δ3ΔLysRΔdctTΔTn6212Δ3ΔLysRΔdctTΔTn6212Δ3ΔLysRΔdctT
Alanine, aspartate and glutamate metabolism 29
-0.106
-0.0901
-0.0166
-0.266
-0.048
0.119
0.0246
-0.173
0.173
0.116
0.0975
0.248
Glycine, serine and threonine metabolism 41
-0.13
-0.0795
-0.0128
-0.277
-0.12
-0.00426
-0.0516
-0.153
0.059
0.0475
-0.00681
0.0474
Cysteine and methionine metabolism 33
-0.103
-0.107
-0.0136
-0.231
0.057
0.0937
0.106
0.0432
-0.00128
-0.041
-0.0612
-0.00206
Valine, leucine and isoleucine degradation 23
-0.0851
-0.0191
-0.00737
-0.24
-0.177
-0.0748
-0.0809
-0.288
0.0798
0.0904
0.024
0.138
Valine, leucine and isoleucine biosynthesis 11
-0.122
-0.114
-0.0396
-0.223
0.245
0.288
0.267
0.302
-0.0907
-0.158
-0.138
-0.142
Lysine biosynthesis 15
-0.182
-0.11
-0.0415
-0.311
0.202
0.238
0.207
0.119
0.0851
0.0258
-0.00893
0.0296
Lysine degradation 21
-0.111
-0.0474
-0.0235
-0.255
-0.315
-0.156
-0.22
-0.262
0.0946
0.119
0.0657
0.182
Arginine biosynthesis 22
-0.1
-0.0726
-0.0207
-0.202
-0.0333
0.0293
-0.0177
-0.119
0.0181
0.0102
-0.000563
0.067
Arginine and proline metabolism 29
-0.111
-0.0838
-0.0314
-0.24
-0.123
0.0236
-0.0352
-0.211
0.0996
0.0452
0.0319
0.141
Histidine metabolism 16
-0.0374
0.0134
-0.0157
-0.06
0.115
0.11
0.111
0.0696
-0.00121
0.00835
-0.0238
0.0401
Tyrosine metabolism 16
-0.147
-0.0767
-0.0721
-0.283
-0.14
-0.0134
-0.0587
-0.309
0.0941
0.0788
0.0209
0.104
Phenylalanine metabolism 22
-0.106
-0.0761
-0.0491
-0.202
-0.111
-0.0337
-0.0138
-0.106
-0.00233
0.0133
-0.0683
0.0156
Tryptophan metabolism 19
-0.112
-0.0495
-0.0231
-0.28
-0.0489
-0.00951
0.0536
-0.0202
0.0652
0.0582
-0.0108
0.0862
Phenylalanine, tyrosine and tryptophan biosynthesis 24
-0.107
-0.0966
-0.0417
-0.209
0.0957
0.12
0.125
0.0856
-0.0175
-0.0886
-0.124
-0.0654

6.1 Metabolism of other amino acids

pathwaygenes glucosesuccinatecitrate
ΔTn6212Δ3ΔLysRΔdctTΔTn6212Δ3ΔLysRΔdctTΔTn6212Δ3ΔLysRΔdctT
beta-Alanine metabolism 11
-0.114
-0.0153
-0.0386
-0.24
-0.291
-0.0429
-0.148
-0.439
0.0795
0.057
0.019
0.118
Taurine and hypotaurine metabolism 3
-0.314
-0.0777
-0.0837
-0.541
-0.555
-0.384
-0.286
-0.321
-0.176
-0.128
-0.239
-0.258
Phosphonate and phosphinate metabolism 5
-0.166
0.0984
-0.242
-0.102
-0.342
-0.303
-0.239
-0.365
0.19
0.41
0.188
0.291
Selenocompound metabolism 7
-0.0643
-0.131
0.026
-0.215
0.28
0.215
0.321
0.455
-0.138
-0.161
-0.163
-0.233
Cyanoamino acid metabolism 7
-0.122
-0.102
0.0107
-0.222
0.311
0.265
0.29
0.303
-0.0329
-0.113
-0.109
-0.0582
D-Glutamine and D-glutamate metabolism 4
-0.15
-0.144
-0.0599
-0.0404
-0.0306
0.0271
-0.000401
0.0698
0.0185
-0.0482
-0.0235
0.0734
D-Alanine metabolism 3
-0.0421
-0.0654
-0.0342
-0.0656
-0.309
-0.139
-0.247
-0.301
0.209
0.114
0.125
0.339
Glutathione metabolism 23
-0.0737
-0.0483
0.00524
-0.188
-0.0278
0.0515
0.0408
-0.101
0.0281
0.00194
-0.0162
0.0451

7.1 Glycan biosynthesis and metabolism

pathwaygenes glucosesuccinatecitrate
ΔTn6212Δ3ΔLysRΔdctTΔTn6212Δ3ΔLysRΔdctTΔTn6212Δ3ΔLysRΔdctT
Glycosaminoglycan degradation 1
0.0615
-0.0094
0.0395
-0.0701
-0.00174
-0.00666
0.0364
-0.0988
0.0952
0.0798
0.00873
0.17
Lipopolysaccharide biosynthesis 24
0.0108
-0.00714
-0.00118
0.0168
0.255
0.219
0.199
0.235
-0.00063
-0.0759
-0.0141
0.00569
Peptidoglycan biosynthesis 20
-0.00631
-0.0448
0.00378
0.0238
0.159
0.166
0.134
0.233
0.0186
-0.065
-0.02
0.0709

8.1 Metabolism of cofactors and vitamins

pathwaygenes glucosesuccinatecitrate
ΔTn6212Δ3ΔLysRΔdctTΔTn6212Δ3ΔLysRΔdctTΔTn6212Δ3ΔLysRΔdctT
Thiamine metabolism 10
-0.0447
-0.0315
0.053
-0.269
-0.0773
-0.011
0.0102
-0.0164
0.0159
-0.0192
-0.0363
0.0416
Riboflavin metabolism 11
-0.0053
-0.0415
0.00638
-0.0418
-0.0773
-0.0099
-0.036
-0.035
-0.0305
-0.0724
-0.05
-0.0632
Vitamin B6 metabolism 9
-0.0475
-0.0403
-0.0398
-0.0909
0.154
0.151
0.129
0.158
-0.0144
-0.0598
-0.0745
-0.0519
Nicotinate and nicotinamide metabolism 22
0.000478
-0.0209
0.0169
-0.0942
-0.096
0.0422
-0.0218
-0.138
0.0964
0.112
0.0681
0.146
Pantothenate and CoA biosynthesis 14
-0.05
-0.0534
-0.0061
-0.0765
0.219
0.214
0.223
0.23
-0.11
-0.173
-0.172
-0.194
Biotin metabolism 18
-0.0076
0.0385
0.00777
-0.0222
0.142
0.113
0.104
0.0797
0.0158
-0.00901
-0.0254
0.0421
Lipoic acid metabolism 2
-0.0101
0.0464
0.0282
0.0691
0.18
0.0079
0.0238
0.207
-0.0094
-0.0464
-0.00793
0.0477
Folate biosynthesis 25
-0.0876
0.0406
-0.0404
-0.123
-0.0725
-0.0381
-0.0968
-0.12
-0.00563
-0.00684
-0.036
-0.0324
One carbon pool by folate 16
-0.144
-0.0615
-0.024
-0.225
0.0621
0.0462
0.122
0.12
-0.0261
-0.135
-0.119
-0.0322
Retinol metabolism 1
-0.0755
-0.0383
-0.0569
-0.329
0.0349
0.121
0.134
-0.079
-0.00972
0.0112
-0.0477
-0.00801
Porphyrin and chlorophyll metabolism 33
-0.0713
-0.0321
-0.0345
-0.0843
0.136
0.143
0.109
0.0161
0.101
0.0735
0.0492
0.139
Ubiquinone and other terpenoid-quinone biosynthesis 15
-0.0854
0.0101
-0.0628
-0.0795
-0.025
0.0213
-0.0118
-0.104
-0.000295
-0.0146
-0.0217
0.039

9.1 Metabolism of terpenoids and polyketides

pathwaygenes glucosesuccinatecitrate
ΔTn6212Δ3ΔLysRΔdctTΔTn6212Δ3ΔLysRΔdctTΔTn6212Δ3ΔLysRΔdctT
Terpenoid backbone biosynthesis 16
0.0252
0.0109
0.0511
0.000857
0.123
0.102
0.108
0.0466
0.084
0.0377
0.0228
0.0847
Zeatin biosynthesis 1
0.183
0.0349
0.0797
0.314
0.0747
0.137
0.0134
0.291
0.0459
0.039
0.0547
0.1
Limonene and pinene degradation 4
-0.153
-0.0514
-0.0363
-0.276
-0.0582
-0.0506
-0.0102
-0.0487
-0.00465
-0.00492
-0.0563
0.0063
Geraniol degradation 7
-0.118
-0.0637
-0.00611
-0.28
-0.0606
-0.0532
-0.0165
-0.124
0.0638
0.0897
0.0274
0.0795
Biosynthesis of ansamycins 1
-0.172
-0.165
-0.0232
-0.396
0.205
0.238
0.245
0.217
0.0982
-0.0635
-0.0243
0.0977
Polyketide sugar unit biosynthesis 6
-0.0472
-0.0236
-0.0162
-0.0624
-0.0473
-0.00286
0.0376
-0.112
0.0314
-0.0127
-0.0203
0.038
Biosynthesis of siderophore group nonribosomal peptides 3
-0.218
-0.251
-0.221
-0.308
-0.0263
0.00872
-0.164
-0.109
0.0831
0.16
0.0242
0.102
Biosynthesis of vancomycin group antibiotics 3
-0.031
-0.0164
0.0184
-0.00493
-0.016
0.0141
0.0325
-0.0362
-0.0744
-0.0947
-0.0918
-0.0883

10.1 Biosynthesis of other secondary metabolites

pathwaygenes glucosesuccinatecitrate
ΔTn6212Δ3ΔLysRΔdctTΔTn6212Δ3ΔLysRΔdctTΔTn6212Δ3ΔLysRΔdctT
Phenylpropanoid biosynthesis 6
-0.069
-0.0548
-0.00482
-0.122
0.0895
0.0977
0.118
0.16
-0.0221
-0.0541
-0.0655
0.0229
Isoquinoline alkaloid biosynthesis 3
-0.0836
-0.0591
-0.0233
-0.257
0.0966
0.135
0.185
-0.00191
0.0467
-0.0828
-0.0772
0.0119
Tropane, piperidine and pyridine alkaloid biosynthesis 4
-0.159
-0.13
-0.0607
-0.31
-0.0645
0.0111
0.0259
-0.196
0.0826
0.0444
0.0187
0.132
Betalain biosynthesis 1
-0.205
-0.104
-0.0718
-0.269
-0.194
0.03
-0.197
-0.478
0.0175
-0.122
0.0263
0.112
Glucosinolate biosynthesis 2
-0.042
-0.0179
-0.0281
-0.171
-0.0121
0.0401
0.0809
-0.00149
0.0979
0.139
0.0784
0.234
Penicillin and cephalosporin biosynthesis 1
-0.128
-0.189
-0.0309
-0.202
0.219
0.29
0.276
0.243
0.0271
-0.085
-0.117
-0.04
Carbapenem biosynthesis 2
-0.0749
-0.135
-0.0169
-0.162
0.0544
0.0902
0.151
-0.0665
0.104
0.0368
0.0291
0.164
Monobactam biosynthesis 10
-0.189
-0.0613
-0.0604
-0.239
0.0589
0.0494
0.0148
0.0654
-0.0931
-0.0818
-0.113
-0.271
Streptomycin biosynthesis 11
-0.0284
-0.0254
0.0212
-0.114
-0.0114
0.0542
0.0528
-0.132
0.0678
0.0256
0.0102
0.105
Acarbose and validamycin biosynthesis 3
-0.0452
-0.00641
0.00589
-0.0138
-0.0464
-0.0394
0.0384
-0.0971
-0.0173
-0.0389
-0.0591
-0.0368
Novobiocin biosynthesis 4
-0.11
-0.104
-0.0761
-0.257
0.118
0.173
0.162
0.00961
0.0539
0.0274
-0.013
0.101
Phenazine biosynthesis 4
-0.139
-0.149
-0.075
-0.173
0.0789
0.127
0.148
0.125
-0.0679
-0.177
-0.168
-0.134
Prodigiosin biosynthesis 8
-0.0479
0.0252
0.0545
-0.131
0.0159
0.00249
-0.0074
0.00474
0.0797
0.0929
0.0714
0.192
Biosynthesis of various secondary metabolites - part 2 2
-0.0831
-0.0484
-0.196
-0.184
0.125
0.0923
0.0876
0.137
-0.379
-0.0782
-0.0845
0.0495
Biosynthesis of various secondary metabolites - part 3 1
-0.424
-0.078
-0.0717
-0.945
-0.226
-0.0176
-0.0877
-1.14
0.329
0.546
0.285
-0.0214

11.1 Xenobiotics biodegradation and metabolism

pathwaygenes glucosesuccinatecitrate
ΔTn6212Δ3ΔLysRΔdctTΔTn6212Δ3ΔLysRΔdctTΔTn6212Δ3ΔLysRΔdctT
Benzoate degradation 19
-0.0974
0.0152
-0.0341
-0.179
-0.114
-0.0785
-0.105
-0.12
-0.0341
-0.0147
-0.0357
0.0309
Aminobenzoate degradation 15
-0.0473
-0.067
0.00278
-0.157
-0.198
-0.183
-0.107
-0.122
0.0432
0.0569
0.00222
0.0797
Fluorobenzoate degradation 5
-0.218
-0.0527
-0.0752
-0.257
-0.318
-0.161
-0.264
-0.332
0.201
0.213
0.317
0.369
Chloroalkane and chloroalkene degradation 5
-0.18
-0.109
-0.0845
-0.33
-0.406
-0.0932
-0.339
-0.474
0.201
0.249
0.141
0.294
Chlorocyclohexane and chlorobenzene degradation 6
-0.21
-0.101
-0.0597
-0.274
-0.431
-0.165
-0.397
-0.441
0.262
0.291
0.35
0.418
Toluene degradation 6
-0.187
-0.0656
-0.0567
-0.246
-0.287
-0.169
-0.241
-0.301
0.182
0.159
0.251
0.284
Xylene degradation 1
-0.0279
-0.13
0.0358
-0.188
-0.131
-0.21
-0.123
-0.149
0.0891
-0.11
-0.0825
-0.143
Nitrotoluene degradation 1
-0.106
-0.13
-0.167
-0.0507
0.223
-0.087
0.192
0.338
-0.176
-0.136
-0.327
-0.0828
Ethylbenzene degradation 2
-0.146
-0.0832
0.0412
-0.367
-0.0327
-0.0197
0.00865
-0.223
0.195
0.282
0.197
0.325
Styrene degradation 8
-0.112
-0.0689
-0.0456
-0.224
-0.0294
-0.0404
0.0533
-0.00117
-0.0235
-0.038
-0.0898
-0.0392
Atrazine degradation 5
-0.00778
0.0739
-0.0287
-0.0458
-0.239
-0.308
-0.421
-0.277
-0.128
0.0816
0.043
0.0445
Caprolactam degradation 7
-0.123
-0.036
-0.0205
-0.252
-0.0759
-0.0491
-0.0349
-0.124
1.09e-05
0.0138
-0.0563
0.0146
Naphthalene degradation 2
-0.375
-0.183
-0.294
-0.543
-0.211
-0.00158
-0.201
-0.5
0.19
0.201
0.145
0.339
Polycyclic aromatic hydrocarbon degradation 1
-0.0174
0.0447
-0.149
0.0272
-0.458
-0.315
-0.422
-0.183
-0.308
-0.563
-0.188
-0.271
Metabolism of xenobiotics by cytochrome P450 7
-0.0737
-0.0456
-0.00585
-0.134
-0.0239
0.0202
0.0305
-0.0908
-0.0316
-0.0363
-0.0444
-0.0302
Drug metabolism - cytochrome P450 8
-0.0677
-0.0398
-0.00491
-0.146
0.014
0.0506
0.0683
-0.062
-0.0186
-0.0555
-0.0559
-0.0299
Drug metabolism - other enzymes 12
-0.101
-0.0503
-0.0359
-0.136
0.0249
0.0911
0.0781
-0.036
-0.00897
-0.0238
-0.0396
0.0383

2. Genetic Information Processing

1.2 Transcription

pathwaygenes glucosesuccinatecitrate
ΔTn6212Δ3ΔLysRΔdctTΔTn6212Δ3ΔLysRΔdctTΔTn6212Δ3ΔLysRΔdctT
RNA polymerase 4
-0.106
-0.0264
-0.0372
-0.227
0.208
0.128
0.141
0.0502
0.0412
0.0459
0.0418
0.0991

2.2 Translation

pathwaygenes glucosesuccinatecitrate
ΔTn6212Δ3ΔLysRΔdctTΔTn6212Δ3ΔLysRΔdctTΔTn6212Δ3ΔLysRΔdctT
Ribosome 36
0.0187
0.118
-0.0262
0.0703
0.367
0.144
0.16
0.356
-0.142
-0.107
-0.116
-0.0949
Aminoacyl-tRNA biosynthesis 24
-0.103
-0.0854
-0.0248
-0.217
0.289
0.299
0.3
0.242
0.0547
-0.0445
-0.039
0.0563
RNA transport 2
0.174
0.0499
0.208
0.204
-0.106
0.022
-0.0515
-0.13
0.0962
-0.0665
0.0886
0.17
Ribosome biogenesis in eukaryotes 1
-0.122
-0.149
-0.05
-0.263
0.0446
0.117
0.131
-0.136
-0.069
-0.128
-0.176
-0.123
Protein export 15
0.0231
0.0707
0.016
0.0756
0.279
0.134
0.131
0.284
-0.0828
-0.109
-0.0832
-0.0846
Protein processing in endoplasmic reticulum 1
0.198
-0.0397
0.246
-0.252
0.97
0.635
0.749
0.939
0.543
0.63
0.441
0.608
Sulfur relay system 15
0.0482
0.121
-0.0515
0.0819
-0.132
-0.284
-0.239
-0.124
-0.0855
-0.0182
0.00274
-0.0107
RNA degradation 17
0.274
-0.085
0.0405
-0.195
0.631
0.294
0.27
0.242
0.465
0.0926
0.091
0.161

4.2 Replication and repair

pathwaygenes glucosesuccinatecitrate
ΔTn6212Δ3ΔLysRΔdctTΔTn6212Δ3ΔLysRΔdctTΔTn6212Δ3ΔLysRΔdctT
DNA replication 17
-0.0349
-0.0467
-0.00549
-0.0296
0.178
0.198
0.162
0.0973
0.0571
0.0253
0.0299
0.0804
Base excision repair 11
-0.00822
-0.0334
0.0296
-0.0619
0.0431
0.0987
0.0886
-0.0688
0.0936
0.0732
0.0597
0.131
Nucleotide excision repair 10
0.0313
-0.0372
0.0652
-0.0786
0.0766
0.159
0.0945
0.0133
0.194
0.16
0.149
0.272
Mismatch repair 20
-0.0307
-0.0668
0.00773
-0.0595
0.174
0.146
0.136
0.0832
0.0596
-0.00366
0.0243
0.0479
Homologous recombination 21
-0.0621
-0.0689
-0.00199
-0.0865
0.155
0.184
0.162
0.0641
0.0705
-0.0207
-0.00616
0.0649
Non-homologous end-joining 2
0.359
0.168
0.423
0.18
-0.384
-0.0327
-0.122
-0.186
0.137
0.415
0.229
0.44
Fanconi anemia pathway 1
0.19
0.0505
0.0778
0.284
0.0505
0.108
0.13
0.347
0.091
-0.0102
-0.0453
-0.0313

3. Environmental Information Processing

1.3 Membrane transport

pathwaygenes glucosesuccinatecitrate
ΔTn6212Δ3ΔLysRΔdctTΔTn6212Δ3ΔLysRΔdctTΔTn6212Δ3ΔLysRΔdctT
ABC transporters 165
-0.06
-0.00969
-0.00175
-0.167
-0.0375
-0.00991
0.0155
0.0209
-0.0358
-0.0422
-0.0656
-0.106
Phosphotransferase system (PTS) 3
0.0101
-0.0134
0.0119
-0.11
-0.0808
-0.000217
-0.0121
-0.155
0.0439
0.109
0.0257
0.179
Bacterial secretion system 48
-0.052
-0.0039
-0.0186
0.0583
0.077
-0.00199
0.0221
0.119
0.0306
0.00485
0.00784
0.0264

2.3 Signal transduction

pathwaygenes glucosesuccinatecitrate
ΔTn6212Δ3ΔLysRΔdctTΔTn6212Δ3ΔLysRΔdctTΔTn6212Δ3ΔLysRΔdctT
Two-component system 192
-0.0331
-0.0137
-0.0086
-0.126
-0.0265
-0.0137
-0.037
-0.0312
0.022
-0.0221
-0.0137
-0.0409
Ras signaling pathway 1
0.25
0.0616
0.315
0.0553
0.0953
0.185
0.221
0.126
0.254
0.237
0.204
0.412
MAPK signaling pathway - fly 2
-0.383
-0.208
-0.158
-0.482
-0.5
-0.309
-0.29
-0.397
0.102
0.065
0.00105
-0.0538
MAPK signaling pathway - plant 3
-0.0765
-0.000195
-0.0121
-0.0492
0.0146
-0.0839
0.0253
0.0733
0.048
0.0483
0.0206
0.0247
MAPK signaling pathway - yeast 1
-0.0612
-0.0768
-0.039
-0.0763
-0.25
-0.363
0.00957
0.111
0.254
0.238
0.152
0.115
HIF-1 signaling pathway 6
0.733
-0.0846
0.0449
-0.293
1.05
0.228
0.231
0.0963
0.905
-0.0453
-0.0331
-0.0415
FoxO signaling pathway 3
-0.276
-0.165
-0.119
-0.347
-0.417
-0.327
-0.19
-0.228
0.153
0.123
0.0513
0.00255
Phosphatidylinositol signaling system 2
0.161
0.146
0.0197
0.173
0.386
0.298
0.294
0.326
-0.0364
-0.0912
-0.0652
-0.0244
Phospholipase D signaling pathway 1
0.25
0.0616
0.315
0.0553
0.0953
0.185
0.221
0.126
0.254
0.237
0.204
0.412
Sphingolipid signaling pathway 1
0.25
0.0616
0.315
0.0553
0.0953
0.185
0.221
0.126
0.254
0.237
0.204
0.412
cAMP signaling pathway 1
0.25
0.0616
0.315
0.0553
0.0953
0.185
0.221
0.126
0.254
0.237
0.204
0.412
PI3K-Akt signaling pathway 1
0.198
-0.0397
0.246
-0.252
0.97
0.635
0.749
0.939
0.543
0.63
0.441
0.608
AMPK signaling pathway 1
-0.0808
-0.102
0.0521
-0.232
-0.145
0.0387
0.00467
-0.312
0.306
0.275
0.252
0.401

4. Cellular Processes

1.4 Transport and catabolism

pathwaygenes glucosesuccinatecitrate
ΔTn6212Δ3ΔLysRΔdctTΔTn6212Δ3ΔLysRΔdctTΔTn6212Δ3ΔLysRΔdctT
Endocytosis 1
0.25
0.0616
0.315
0.0553
0.0953
0.185
0.221
0.126
0.254
0.237
0.204
0.412
Peroxisome 9
-0.136
-0.118
-0.0578
-0.167
-0.143
-0.112
-0.0579
-0.089
0.0631
0.0304
-0.0117
-0.0244

2.4 Cell growth and death

pathwaygenes glucosesuccinatecitrate
ΔTn6212Δ3ΔLysRΔdctTΔTn6212Δ3ΔLysRΔdctTΔTn6212Δ3ΔLysRΔdctT
Cell cycle - Caulobacter 16
-0.0594
-0.0681
-0.015
-0.053
-0.0296
-0.0128
-0.09
0.0245
0.0464
0.0841
0.0536
0.136
Apoptosis 2
0.171
0.275
-0.00234
0.189
-0.226
-0.198
-0.216
-0.252
0.0179
0.0988
0.0251
-0.000204
Apoptosis - fly 2
0.101
0.249
0.0557
0.119
-0.0383
-0.0974
-0.093
-0.187
0.0917
0.201
0.0933
0.0376
Apoptosis - multiple species 1
0.469
0.67
0.117
0.766
0.0556
-0.0782
-0.163
-0.116
0.00977
0.223
0.0869
-0.0867
Ferroptosis 2
-0.0721
-0.173
0.0108
-0.172
0.342
0.246
0.315
0.335
-0.135
-0.297
-0.25
-0.272
Necroptosis 6
-0.0987
-0.123
0.00608
-0.311
0.063
0.149
0.152
-0.117
0.209
0.168
0.123
0.26
p53 signaling pathway 1
0.469
0.67
0.117
0.766
0.0556
-0.0782
-0.163
-0.116
0.00977
0.223
0.0869
-0.0867
Quorum sensing 87
-0.00897
0.0124
0.025
-0.105
-0.0403
-0.00838
-0.0099
-0.011
0.00638
-0.0233
-0.0329
-0.0155
Biofilm formation - Vibrio cholerae 26
0.0701
0.0545
0.0591
0.0704
-0.126
-0.0897
-0.156
-0.131
0.0267
0.0397
0.0282
0.0868
Biofilm formation - Pseudomonas aeruginosa 58
-0.0859
0.00225
-0.0522
-0.0697
-0.11
-0.0791
-0.101
-0.0648
-0.0506
-0.0658
-0.0498
-0.052
Biofilm formation - Escherichia coli 30
0.00442
-0.0112
-0.00195
0.0037
-0.0679
-0.0224
-0.0464
-0.0509
-0.00873
-0.0042
-0.0147
0.005

5.4 Cell motility

pathwaygenes glucosesuccinatecitrate
ΔTn6212Δ3ΔLysRΔdctTΔTn6212Δ3ΔLysRΔdctTΔTn6212Δ3ΔLysRΔdctT
Bacterial chemotaxis 80
-0.0327
-0.0188
0.00046
-0.248
-0.0662
-0.0545
-0.0884
-0.137
0.0576
0.00963
0.00563
-0.0249
Flagellar assembly 37
-0.154
-0.00136
-0.0763
-0.172
-0.344
-0.255
-0.41
-0.504
0.056
0.0459
0.0804
0.136

5. Organismal Systems

1.5 Immune system

pathwaygenes glucosesuccinatecitrate
ΔTn6212Δ3ΔLysRΔdctTΔTn6212Δ3ΔLysRΔdctTΔTn6212Δ3ΔLysRΔdctT
NOD-like receptor signaling pathway 5
-0.1
-0.0715
-0.0209
-0.175
0.356
0.187
0.236
0.293
0.0692
0.0444
0.0581
-0.12
Antigen processing and presentation 1
0.198
-0.0397
0.246
-0.252
0.97
0.635
0.749
0.939
0.543
0.63
0.441
0.608
Th17 cell differentiation 1
0.198
-0.0397
0.246
-0.252
0.97
0.635
0.749
0.939
0.543
0.63
0.441
0.608
IL-17 signaling pathway 1
0.198
-0.0397
0.246
-0.252
0.97
0.635
0.749
0.939
0.543
0.63
0.441
0.608
Fc gamma R-mediated phagocytosis 1
0.25
0.0616
0.315
0.0553
0.0953
0.185
0.221
0.126
0.254
0.237
0.204
0.412

2.5 Endocrine system

pathwaygenes glucosesuccinatecitrate
ΔTn6212Δ3ΔLysRΔdctTΔTn6212Δ3ΔLysRΔdctTΔTn6212Δ3ΔLysRΔdctT
Insulin signaling pathway 2
-0.0447
-0.0347
0.054
-0.24
-0.31
-0.0201
-0.105
-0.412
0.255
0.295
0.215
0.415
Glucagon signaling pathway 3
-0.0913
-0.0802
0.0298
-0.308
-0.089
0.115
0.0555
-0.22
0.214
0.187
0.125
0.298
Adipocytokine signaling pathway 2
-0.0721
-0.173
0.0108
-0.172
0.342
0.246
0.315
0.335
-0.135
-0.297
-0.25
-0.272
PPAR signaling pathway 6
-0.0905
-0.115
0.00262
-0.248
0.195
0.192
0.227
0.132
-0.0477
-0.106
-0.15
-0.101
GnRH signaling pathway 1
0.25
0.0616
0.315
0.0553
0.0953
0.185
0.221
0.126
0.254
0.237
0.204
0.412
Estrogen signaling pathway 1
0.198
-0.0397
0.246
-0.252
0.97
0.635
0.749
0.939
0.543
0.63
0.441
0.608
Progesterone-mediated oocyte maturation 1
0.198
-0.0397
0.246
-0.252
0.97
0.635
0.749
0.939
0.543
0.63
0.441
0.608
Thyroid hormone synthesis 4
-0.0921
-0.0104
-0.0496
-0.154
-0.215
-0.0948
-0.159
-0.286
0.0339
-0.0284
0.003
0.0384
Thyroid hormone signaling pathway 1
-0.04
-0.0216
-0.183
-0.0923
-0.241
-0.315
-0.245
0.00753
-0.0019
-0.00492
0.0441
0.00111
Parathyroid hormone synthesis, secretion and action 1
0.25
0.0616
0.315
0.0553
0.0953
0.185
0.221
0.126
0.254
0.237
0.204
0.412

5.5 Excretory system

pathwaygenes glucosesuccinatecitrate
ΔTn6212Δ3ΔLysRΔdctTΔTn6212Δ3ΔLysRΔdctTΔTn6212Δ3ΔLysRΔdctT
Proximal tubule bicarbonate reclamation 1
-0.248
-0.238
-0.117
-0.111
-0.181
-0.237
-0.0671
0.00735
-0.224
-0.262
-0.179
-0.162

6.5 Nervous system

pathwaygenes glucosesuccinatecitrate
ΔTn6212Δ3ΔLysRΔdctTΔTn6212Δ3ΔLysRΔdctTΔTn6212Δ3ΔLysRΔdctT
Glutamatergic synapse 6
-0.13
-0.151
-0.0114
-0.237
-0.0339
0.0479
0.0884
-0.166
0.0896
0.00612
0.0238
0.128
GABAergic synapse 5
-0.206
-0.194
-0.0766
-0.296
-0.0598
0.0205
0.0619
-0.225
0.0566
-0.0401
-0.0123
0.0718
Dopaminergic synapse 1
-0.026
0.000583
0.00162
-0.225
0.279
0.263
0.333
0.139
0.0722
-0.19
-0.136
-0.0276
Serotonergic synapse 1
-0.026
0.000583
0.00162
-0.225
0.279
0.263
0.333
0.139
0.0722
-0.19
-0.136
-0.0276
Retrograde endocannabinoid signaling 1
-0.142
-0.0863
-0.0656
-0.339
-0.0525
-0.0415
0.0822
-0.33
0.0967
-0.0252
0.00162
0.0297

9.5 Aging

pathwaygenes glucosesuccinatecitrate
ΔTn6212Δ3ΔLysRΔdctTΔTn6212Δ3ΔLysRΔdctTΔTn6212Δ3ΔLysRΔdctT
Longevity regulating pathway 3
-0.276
-0.165
-0.119
-0.347
-0.417
-0.327
-0.19
-0.228
0.153
0.123
0.0513
0.00255
Longevity regulating pathway - worm 12
-0.0835
-0.0838
0.0108
-0.203
0.0215
0.00984
0.0579
-0.00764
0.155
0.159
0.104
0.144
Longevity regulating pathway - multiple species 5
-0.183
-0.112
-0.0721
-0.231
-0.262
-0.203
-0.156
-0.217
0.296
0.333
0.245
0.298

10.5 Environmental adaptation

pathwaygenes glucosesuccinatecitrate
ΔTn6212Δ3ΔLysRΔdctTΔTn6212Δ3ΔLysRΔdctTΔTn6212Δ3ΔLysRΔdctT
Thermogenesis 3
-0.0571
-0.135
-0.00409
-0.15
0.418
0.288
0.363
0.429
-0.0943
-0.223
-0.175
-0.188
Plant-pathogen interaction 9
-0.0718
-0.108
-0.00782
-0.24
0.293
0.217
0.247
0.291
0.0817
0.039
-0.00317
-0.0523

6. Human Diseases

3.6 Immune disease

pathwaygenes glucosesuccinatecitrate
ΔTn6212Δ3ΔLysRΔdctTΔTn6212Δ3ΔLysRΔdctTΔTn6212Δ3ΔLysRΔdctT
Primary immunodeficiency 2
-0.101
-0.102
-0.0719
-0.186
-0.14
-0.132
-0.106
-0.435
0.092
0.147
0.118
0.238

4.6 Neurodegenerative disease

pathwaygenes glucosesuccinatecitrate
ΔTn6212Δ3ΔLysRΔdctTΔTn6212Δ3ΔLysRΔdctTΔTn6212Δ3ΔLysRΔdctT
Alzheimer disease 4
0.0313
0.0925
0.00219
-0.000654
0.0769
0.0828
0.0997
0.0583
0.00162
-0.00792
-0.0261
-0.048
Parkinson disease 1
0.469
0.67
0.117
0.766
0.0556
-0.0782
-0.163
-0.116
0.00977
0.223
0.0869
-0.0867
Amyotrophic lateral sclerosis (ALS) 6
0.0116
0.0954
-0.0101
0.0778
-0.214
-0.142
-0.161
-0.221
0.0939
0.111
0.0992
0.0838
Huntington disease 7
-0.0908
0.0332
-0.0483
-0.0602
-0.291
-0.158
-0.223
-0.319
0.0736
0.0798
0.0637
0.04
Spinocerebellar ataxia 1
-0.255
-0.171
0.00424
-0.46
0.187
0.181
0.266
0.141
-0.00518
-0.101
-0.109
-0.156
Prion diseases 1
-0.1
-0.0496
0.00442
0.163
-0.324
-0.0437
-0.217
-0.238
0.231
0.33
0.299
0.422

5.6 Substance dependence

pathwaygenes glucosesuccinatecitrate
ΔTn6212Δ3ΔLysRΔdctTΔTn6212Δ3ΔLysRΔdctTΔTn6212Δ3ΔLysRΔdctT
Cocaine addiction 1
-0.026
0.000583
0.00162
-0.225
0.279
0.263
0.333
0.139
0.0722
-0.19
-0.136
-0.0276
Amphetamine addiction 1
-0.026
0.000583
0.00162
-0.225
0.279
0.263
0.333
0.139
0.0722
-0.19
-0.136
-0.0276
Alcoholism 1
-0.026
0.000583
0.00162
-0.225
0.279
0.263
0.333
0.139
0.0722
-0.19
-0.136
-0.0276

6.6 Cardiovascular disease

pathwaygenes glucosesuccinatecitrate
ΔTn6212Δ3ΔLysRΔdctTΔTn6212Δ3ΔLysRΔdctTΔTn6212Δ3ΔLysRΔdctT
Fluid shear stress and atherosclerosis 10
-0.0676
-0.0517
0.0087
-0.126
0.12
0.0792
0.111
0.0539
-0.00046
-0.0088
-0.0058
-0.0123
Viral myocarditis 1
0.469
0.67
0.117
0.766
0.0556
-0.0782
-0.163
-0.116
0.00977
0.223
0.0869
-0.0867

7.6 Endocrine and metabolic disease

pathwaygenes glucosesuccinatecitrate
ΔTn6212Δ3ΔLysRΔdctTΔTn6212Δ3ΔLysRΔdctTΔTn6212Δ3ΔLysRΔdctT
Type II diabetes mellitus 1
-0.185
-0.171
-0.0187
-0.443
0.353
0.384
0.376
0.166
0.132
-0.0293
-0.055
0.063
Type I diabetes mellitus 1
0.315
-0.0322
0.313
-0.206
1.07
0.678
0.846
0.942
0.598
0.626
0.471
0.608
Non-alcoholic fatty liver disease (NAFLD) 1
0.469
0.67
0.117
0.766
0.0556
-0.0782
-0.163
-0.116
0.00977
0.223
0.0869
-0.0867
Insulin resistance 2
-0.103
-0.0759
0.0404
-0.307
-0.11
0.0693
-0.0176
-0.259
0.116
0.0279
0.00195
0.203
Cushing syndrome 2
-0.315
-0.107
-0.0561
-0.583
-0.361
0.0347
-0.229
-0.38
0.247
0.263
0.166
0.142
Epithelial cell signaling in Helicobacter pylori infection 5
-0.0244
-0.0708
0.0277
-0.136
-0.0539
-0.0646
-0.144
-0.0118
0.0577
0.0722
-0.0123
0.0926
Pathogenic Escherichia coli infection 4
0.0313
0.0925
0.00219
-0.000654
0.0769
0.0828
0.0997
0.0583
0.00162
-0.00792
-0.0261
-0.048
Salmonella infection 4
-0.156
-0.127
-0.066
-0.191
0.0658
0.0187
0.000346
0.0286
0.0434
0.0164
0.0603
-0.172
Shigellosis 4
0.00188
0.104
0.0237
-0.0868
0.0957
0.0201
0.0287
0.0501
0.0561
0.0965
-0.00374
-0.146
Yersinia infection 1
-0.223
-0.172
-0.216
0.167
0.52
0.178
0.315
0.876
-0.049
-0.174
-0.102
-0.69
Pertussis 9
0.0561
0.0452
0.0618
0.0447
-0.0309
-0.0754
-0.0195
0.0765
0.0712
0.105
0.0698
0.0668
Legionellosis 5
0.0963
0.0697
0.0922
-0.105
0.44
0.343
0.351
0.361
0.172
0.154
0.108
0.111
Staphylococcus aureus infection 1
0.0651
-0.0559
-0.028
0.0835
0.031
-0.0126
0.0127
0.153
-0.0679
-0.154
-0.0878
-0.0685
Tuberculosis 7
0.113
0.0341
0.0904
-0.109
0.515
0.339
0.368
0.517
0.198
0.235
0.182
0.166
Human immunodeficiency virus 1 infection 1
0.469
0.67
0.117
0.766
0.0556
-0.0782
-0.163
-0.116
0.00977
0.223
0.0869
-0.0867
Measles 1
0.469
0.67
0.117
0.766
0.0556
-0.0782
-0.163
-0.116
0.00977
0.223
0.0869
-0.0867
Influenza A 1
0.469
0.67
0.117
0.766
0.0556
-0.0782
-0.163
-0.116
0.00977
0.223
0.0869
-0.0867
Hepatitis B 1
0.469
0.67
0.117
0.766
0.0556
-0.0782
-0.163
-0.116
0.00977
0.223
0.0869
-0.0867
Hepatitis C 1
0.469
0.67
0.117
0.766
0.0556
-0.0782
-0.163
-0.116
0.00977
0.223
0.0869
-0.0867
Herpes simplex virus 1 infection 1
0.469
0.67
0.117
0.766
0.0556
-0.0782
-0.163
-0.116
0.00977
0.223
0.0869
-0.0867
Human cytomegalovirus infection 1
0.469
0.67
0.117
0.766
0.0556
-0.0782
-0.163
-0.116
0.00977
0.223
0.0869
-0.0867
Kaposi sarcoma-associated herpesvirus infection 1
0.469
0.67
0.117
0.766
0.0556
-0.0782
-0.163
-0.116
0.00977
0.223
0.0869
-0.0867
Epstein-Barr virus infection 1
0.469
0.67
0.117
0.766
0.0556
-0.0782
-0.163
-0.116
0.00977
0.223
0.0869
-0.0867
Human papillomavirus infection 1
-0.185
-0.171
-0.0187
-0.443
0.353
0.384
0.376
0.166
0.132
-0.0293
-0.055
0.063
Toxoplasmosis 1
0.469
0.67
0.117
0.766
0.0556
-0.0782
-0.163
-0.116
0.00977
0.223
0.0869
-0.0867
Chagas disease (American trypanosomiasis) 1
-0.117
-0.125
-0.0168
-0.352
0.048
0.0825
0.0605
-0.0904
0.068
0.0034
-0.0577
0.0425
African trypanosomiasis 2
-0.101
-0.00587
-0.0667
-0.183
-0.0244
-0.121
-0.0764
-0.138
-0.101
-0.0917
-0.112
-0.0918
beta-Lactam resistance 15
-0.0419
-0.0932
0.00611
-0.129
0.206
0.208
0.197
0.252
-0.0199
-0.148
-0.107
-0.0669
Vancomycin resistance 5
-0.0753
-0.0734
-0.0574
0.00434
-0.184
-0.0643
-0.182
-0.127
0.124
0.0707
0.108
0.27
Cationic antimicrobial peptide (CAMP) resistance 26
-0.0144
-0.0487
0.0029
-0.0739
0.0791
0.0403
0.104
0.16
0.0244
-0.0304
-0.0157
0.0334
Platinum drug resistance 8
-0.00476
0.0459
0.0311
-0.00742
-0.0249
-0.0105
-0.0233
-0.11
-0.0152
0.00478
-0.0185
-0.0219
Antifolate resistance 4
-0.157
-0.102
-0.0143
-0.26
0.424
0.4
0.411
0.379
-0.0699
-0.208
-0.162
-0.0534

10.6 Environmental adaptation

pathwaygenes glucosesuccinatecitrate
ΔTn6212Δ3ΔLysRΔdctTΔTn6212Δ3ΔLysRΔdctTΔTn6212Δ3ΔLysRΔdctT
Pathways in cancer 11
-0.0139
0.018
0.053
-0.11
0.0178
0.0757
0.039
-0.0334
0.099
0.123
0.0729
0.0922
MicroRNAs in cancer 1
-0.248
-0.238
-0.117
-0.111
-0.181
-0.237
-0.0671
0.00735
-0.224
-0.262
-0.179
-0.162
Chemical carcinogenesis 7
-0.0737
-0.0456
-0.00585
-0.134
-0.0239
0.0202
0.0305
-0.0908
-0.0316
-0.0363
-0.0444
-0.0302
Viral carcinogenesis 1
-0.185
-0.171
-0.0187
-0.443
0.353
0.384
0.376
0.166
0.132
-0.0293
-0.055
0.063
Central carbon metabolism in cancer 4
-0.116
-0.132
0.0023
-0.216
0.0729
0.0976
0.172
0.0835
0.0222
-0.0533
-0.0408
0.0245
Choline metabolism in cancer 1
0.25
0.0616
0.315
0.0553
0.0953
0.185
0.221
0.126
0.254
0.237
0.204
0.412
Colorectal cancer 1
0.469
0.67
0.117
0.766
0.0556
-0.0782
-0.163
-0.116
0.00977
0.223
0.0869
-0.0867
Pancreatic cancer 1
0.25
0.0616
0.315
0.0553
0.0953
0.185
0.221
0.126
0.254
0.237
0.204
0.412
Hepatocellular carcinoma 6
-0.0734
-0.0468
0.00266
-0.102
-0.0337
0.00348
0.0133
-0.0927
-0.0352
-0.0442
-0.0438
-0.0339
Renal cell carcinoma 2
-0.315
-0.107
-0.0561
-0.583
-0.361
0.0347
-0.229
-0.38
0.247
0.263
0.166
0.142
Prostate cancer 1
0.198
-0.0397
0.246
-0.252
0.97
0.635
0.749
0.939
0.543
0.63
0.441
0.608
Small cell lung cancer 1
0.469
0.67
0.117
0.766
0.0556
-0.0782
-0.163
-0.116
0.00977
0.223
0.0869
-0.0867